What is the recommended duration of treatment for oral candidiasis with fluconazole?

What is the recommended duration of treatment for oral candidiasis with fluconazole?

• A. 3 to 5 days
• B. 7 to 14 days
• C. 15 to 20 days
• D. 1 to 3 days

Answer: (B)

The recommended duration of treatment for oral candidiasis with fluconazole is 7 to 14 days. This timeframe allows sufficient time for the antifungal agent to effectively inhibit the growth of Candida species, which are typically responsible for oral thrush. Fluconazole works by disrupting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby causing cell death. In mild cases, a shorter treatment duration may occasionally be sufficient; however, the 7 to 14 days window is considered optimal for most patients to ensure the infection is thoroughly eradicated and to reduce the risk of recurrence. This approach is particularly important given that oral candidiasis can occur in immunocompromised individuals, where a more aggressive treatment strategy is warranted to prevent potential complications.

The recommended duration of treatment for oral candidiasis with fluconazole is 7 to 14 days. This timeframe allows sufficient time for the antifungal agent to effectively inhibit the growth of Candida species, which are typically responsible for oral thrush. Fluconazole works by disrupting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby causing cell death.

In mild cases, a shorter treatment duration may occasionally be sufficient; however, the 7 to 14 days window is considered optimal for most patients to ensure the infection is thoroughly eradicated and to reduce the risk of recurrence. This approach is particularly important given that oral candidiasis can occur in immunocompromised individuals, where a more aggressive treatment strategy is warranted to prevent potential complications.