Name a key adverse effect that should be monitored in patients receiving amphotericin B.

Name a key adverse effect that should be monitored in patients receiving amphotericin B.

• A. Gastrointestinal bleeding
• B. Renal function
• C. Cardiac function
• D. Electrolyte levels

Answer: (B)

Monitoring renal function is crucial for patients receiving amphotericin B due to its well-documented nephrotoxicity. Amphotericin B can lead to acute kidney injury by causing damage to the renal tubules, which can result in decreased glomerular filtration rate and electrolyte imbalances. Clinicians often assess renal function through serum creatinine levels and urine output to ensure early detection and management of any renal impairment that may arise during treatment. In addition to renal function, while monitoring electrolyte levels is also important (as amphotericin B can cause hypokalemia and hypomagnesemia), the primary concern typically highlighted in clinical guidelines is the direct impact on kidney function. Therefore, prioritizing renal function monitoring is essential in mitigating potential adverse effects of amphotericin B therapy.

Monitoring renal function is crucial for patients receiving amphotericin B due to its well-documented nephrotoxicity. Amphotericin B can lead to acute kidney injury by causing damage to the renal tubules, which can result in decreased glomerular filtration rate and electrolyte imbalances. Clinicians often assess renal function through serum creatinine levels and urine output to ensure early detection and management of any renal impairment that may arise during treatment.

In addition to renal function, while monitoring electrolyte levels is also important (as amphotericin B can cause hypokalemia and hypomagnesemia), the primary concern typically highlighted in clinical guidelines is the direct impact on kidney function. Therefore, prioritizing renal function monitoring is essential in mitigating potential adverse effects of amphotericin B therapy.